Tolerance to the diuretic effects of cannabinoids and cross-tolerance to a kappa-opioid agonist in THC-treated mice
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Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a κ-Opioid Agonist in THC-Treated Mice.
Daily treatment with cannabinoids results in tolerance to many, but not all, of their behavioral and physiologic effects. The present studies investigated the effects of 7-day exposure to 10 mg/kg daily of Δ(9)-tetrahydrocannabinol (THC) on the diuretic and antinociceptive effects of THC and the synthetic cannabinoid AM4054. Comparison studies determined diuretic responses to the κ-opioid agoni...
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Recent studies in our laboratory have shown that in mice, low doses of morphine in combination with Delta(9)-tetrahydrocannabinol (Delta(9)-THC) have a similar antinociceptive effect to high doses of morphine alone. After short-term administration of this combination, there is no behavioral tolerance to the opioid. Previous binding studies and Western analyses following chronic morphine exposur...
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The analgesic effects of opioids, such as morphine and codeine, in mice are enhanced by oral administration of the cannabinoid -tetrahydrocannabinol ( -THC). However, isobolographic analysis has never been done to confirm a synergy between -THC and morphine or codeine via oral routes of administration. To determine the nature of the interaction between these drugs for pain relief and extend pre...
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Opioid receptor agonists are effective for treating pain; however, tolerance and dependence can develop with repeated use. Combining opioids with cannabinoids can enhance their analgesic potency, although it is less clear whether combined treatment alters opioid tolerance and dependence. In this study, four monkeys received 3.2 mg/kg morphine alone or in combination with 1 mg/kg Δ(9)-tetrahydro...
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تاریخ انتشار 2016